Textbook of Drug Design and Discovery

Textbook of Drug Design and Discovery, Fifth Edition, offers an exhaustive resource that has been thoroughly revised and updated to reflect the latest trends in drug design and discovery. Aimed at students and professionals in chemistry, pharmacy, pharmacology, biochemistry, and medicine, this edition emphasizes an educational approach while presenting a clear and contemporary review of the field. Beginning with a detailed introduction, the initial portion of the book explores the essentials of molecular recognition, ligand-based strategies, and biostructure-based design. The authors delve into drug-like properties and critical decision-making in medicinal chemistry, extending the discussion to chemical biology, the role of natural products, and the application of in vivo imaging in drug discovery. In its later sections, the textbook navigates through peptide and protein drug design, the use of prodrugs, and the development of enzyme inhibitors. Furthermore, it examines the structure, function, and pharmacology of receptors, along with the intricate workings of ion channels and neurotransmitter transporters. Subsequent chapters focus on key neurotransmitter systems - including GABA, glutamic acid, acetylcholine, histamine, dopamine, serotonin, opioids, and cannabinoids - culminating in a discussion on neglected diseases, anticancer agents, tyrosine kinase receptors, and antibiotics.