Textbook of Drug Design and Discovery

Textbook of Drug Design and Discovery, Fourth Edition, offers a comprehensive exploration of the rapidly evolving field of drug research. Against a backdrop of breakthroughs in molecular biology and human genome mapping, this text provides a solid foundation in advanced synthetic chemistry, computational chemistry, biochemistry, structural biology, and molecular pharmacology. Classroom tested and highly regarded by students, the book details the strategies medicinal chemists use to transform new scientific insights into promising lead compounds and ultimately into clinical drug candidates. The text is thoughtfully organized into two parts – one that introduces the fundamental principles and methods of drug design, and another that focuses on specific targets and diseases. New topics include biostructure-based and ligand-based drug design, chemical biology, natural products, imaging techniques, and studies on neurotransmitter transporters, among others. Enhanced with over 300 color figures and 24 tables, each chapter provides the historical background needed to place modern research into context, comprehensive references for further study, and clear conclusions that summarize key emerging areas in drug discovery. This edition stands as an essential resource for students and professionals alike, equipping them with the multidisciplinary insights required in today’s competitive field of drug design.