Principles of Pharmacology

The Fourth Edition of Principles of Pharmacology by David E. Golan masterfully combines a mechanism-based and systems-based approach with a clear, accessible format. This edition, published in 2016 by Lww, has been carefully updated to reflect the latest developments in pharmacology, making it an indispensable resource for both students and instructors. Each chapter opens with a clinical vignette that sets the stage with a therapeutic challenge, followed by an in-depth discussion of the biochemical, physiological, and pathophysiological foundations of the system in focus. The text then explores the pharmacology of drugs and drug classes that target specific molecular and cellular components, providing a thorough examination of drug-receptor interactions, pharmacodynamics, toxicity, and pharmacogenomics. Notable enhancements in this edition include comprehensive revisions throughout the text, a new chapter dedicated to drug transporters, and a wealth of updated and colorized illustrations that clarify key concepts. Carefully organized sections focusing on fundamental principles and major therapeutic areas, along with summary tables of pivotal drug information, ensure that complex topics are conveyed with clarity and precision.